While I don't ever scan as high as the OP, I do scan my 8x10 film at 1200 dpi, which yields an 8-bit file of around 320Mb.
Thus far, I've had no trouble editing these in LR.
Have a look at this article: http://www.onlandscape.co.uk/2012/03...our-photoshop/
Adobe has several pages on optimizing all aspects of Lightroom:
https://helpx.adobe.com/lightroom/kb...lightroom.html
https://helpx.adobe.com/lightroom/kb...nce-hints.html
I found these documents quite helpful, especially the recommendation to use Photoshop for large numbers of spot-healing corrections. In addition, I was able to substantially decrease the size of my Lightroom Previews file by actually measuring the size of a preview (in pixels) with my normal working configuration of panes. Even with a 27-inch NEC display, it was smaller than I realized, and so I deleted the previews, and was able to choose a smaller standard size (1440 pixels) in the catalog settings for subsequent preview building.
http://cbcampbell.com
@cbcampbell707
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