I used to use Hugin due to the control it gave, but it went through a few versions of being buggy on a Mac, the most annoying of which was it wouldn't work if the source images were in a path that had spaces in the name. I didn't have problems under Windows or Linux.
I purchased Autopano Pro when doing some 50 - 300 image digital stitches, and it found it to be far faster and more stable than Hugin or PS (CS3). It is much more forgiving when doing hand-held stitches (less of an issue with large format!), and I've always had better results with areas that are featureless or where there are moving objects (like the sea). I did some stitches for a friend as a trial stitching a couple of 4x10 (IIRC) shots, and for another with three 4x5 shots.
Hugin is definitely worth trying - it does have a guided mode, but if you want to poke around under the hood, there's a wealth of manual options.
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