You will want to preflight them on a printer, but you won't easily learn all the ins and outs of printing huge prints simply by dicking around with consumer grade Epson printers and prosumer software. Find a commercial fine art printer who has the spendy uprezzing RIPs (subscription key and dongle type that are licensed per machine, and for which these folks often pay thousands annually, not just uprezzing from CS5), and you might just be amazed at how good a 6 foot print from a 10MP or 12MP DSLR can look.
That is, provided you used top flight glass and technique in the first place, and did everything right in the post processing stages.
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