I've had a Wacom Intuos III for years. For me it was a waste of money, I still use a mouse most of the time. I bought it mainly to be able to use the pen for making fine selections with the lasso tools but as I've become more knowledgeable about Photoshop I rarely make selections that way any more. There was nothing else about the tablet that I found useful.
I'm not so sure about using the pen to relieve your wrist stress. I'm no doctor so I don't know what different muscles, ligaments, tendons, etc. are used with the pen vs. the mouse but when I hold the pen in my hand and use it on the tablet my hand and wrist feel about the same as when I hold the mouse.
Mine is 9x6 or something like that. I got that size rather than the larger size because I figured I wouldn't have to move my arm and hand around as much with the smaller area.
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