With 4x5, and a film such as TMX, or perhaps even TMY grain will not be obtrusive.
The problem with 4x5 compared to 35mm is smaller apertures, unless you plan to shoot wide open. Regardless of the aperture, you will need four times the strobe output for a 25 ISO film than for a 100 ISO film. That may get pricey depending on your lighting set-up.
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