I enjoy using my Epson 4990 with Epson Scan, and I’m curious if the lens responds to one’s choice between “film area guide” vs. “film holder.”

My experiments indicate not – even though the software allows me to make this choice.

But then it occurred to me that the 4990’s DOF may be wide enough to conceal any subtle changes being made.

Or is this option only for the newer Epson models, the v700 v750 (or pro) versions? (If so, what actually changes?)