For in Seattle try the Space Needle, the EMP (as already suggested),the Chihuly Garden and Glass (handheld photography only so not large format friendly), if you're into butterflies there's a butterfly exhibit at the Pacific Science Center, which begs the actual Pacific Science Center. All of these are within the Seattle Center so if only one is of interest it's only one location. If you don't like the insides, you should like the outsides, depending on the weather. Depending on when you're here the weather can be a real challenge. Actually, even if you're here in summer the weather can be a challenge.
http://www.chihulygardenandglass.com/plan-your-visit
http://www.pacificsciencecenter.org/
http://www.spaceneedle.com/home/
http://www.empmuseum.org/
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