I had my Sprintscan 45 running years ago daisy chained with a Sprintscan 35 plus, but currently I only run the Sprintscan 45 on SCSI and a Nikon Supercoolscan 5000 which uses USB.
I recently built a new PC and used an AMD processor this time. The SCSI card installed without any trouble from XP. I then installed the Polacolor Insight software and only had it install the drivers for the Sprintscan 45. It worked perfect the first time.
Make sure you have your SCSI chain terminated. Make sure your scanner is powered on before you turn your computer on.
Go online and download the newest version of Polacolor Insight version 5. (which is actually several years old now .) Don't use any software CDs that came with the Sprintscan 45. The ones I have that came with my scanner, back when I got it, wont work for me either I found. Only the downloaded software would install for me.
In regards to cleaning. Don't work inside the case with the power on. After un-plugging the scanner, take the lid off and carefully clean the mirror and lens. Your scans will be terrible if you don't. I also tweaked the position of the lens, through trial and error, and made my scans sharper. The scanner really holds its' own in tests I have done against the Imacon 848 and the Epson 750. For an old unit, it isn't half bad.
With regard to display lights. When I power on, the orange light is lit and then the green light comes on without flashing. I will need to check, but the green light flashes only when the scanning carriage is moving or calibrating. I can post later to confirm this when I have the scanner running.
Edit added: I checked my scanner, and the green light comes on without flashing when the scanner is turned on and ready. It stays on and only flashes when a scan is in progress. After the scan is complete, the green light burns steady indicating the scanner is ready for the next job.
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