I can only really speak personaly to a comparison of Mamiya 7II and 80mm lens with a high quality lens on a quality 4X5 system. The comparison film was Portra 160, and the MF and LF film was drum scanned.
In terms of absolute image quality the 4X5" negative did beat the 6X7 cm negative, but only by a tad. In a print I don't think you would see any difference at all in sharpness until going beyond 30X35" in size, but you might see a bit more grain in the print from the MF negative, but not necessarily as use of noise reduction software might neutralize grain.
This comparison was made same film for both formats. Bear in mind that for the same DOF you can use a slower speed film with finer grain and greater sharpness with MF than with 4X5, or you can use an aperture of about 1.5 stops greater, with less diffraction.
Either way, for maximum image quality individual technique is probably more important than the format. Grain, for example, will depend highly on how you print, scan, what scanner, technique used, fluid mounted or not, etc.
Sandy King
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