DOF has everything to do with print size, since it is a function of enlargement - the point at which a defocused fuzzy circle (circle of confusion or CoC) will still appear to be a point. Viewing distance is also a factor, as is the average resolving power of the human eye.
Most/many DOF calcutors assume a print size of 8x10 and a viewing distance of 250mm, and assign different CoC values to each film format size based on the degree of enlargement required to produce an 8x10 print. Some are more conservative with the CoC value, some more liberal.
Since the target print size is 20" x 40" from the 6x17 negs, it might be more reliable to manually calculate the CoC from the diagonal of the target print size, and modify a DOF calculator accordingly. Or, one might just use the CoC for 6x6, based on the assumption that the narrow dimension will produce more conservative (closer to "tack sharp") results.
Wikipedia has a fairly good explanation:
http://en.wikipedia.org/wiki/Circle_of_confusion
Bookmarks