A Flextight 848/949/X5 will give you about a 420MB 16-bit file from 4x5 after trimming. This translates to a 24x30 print (with a 1.5" border) at Epson's optimal 360ppi. I scan trannies on my 848 with no cropping/resizing and print with no driver resampling to an Epson 7800 ... the scanner and printer are a great match. The earlier Precision scanners aren't in the same league (I used to have one).
Higher resolution scans may help with grain aliasing but with the Fujichrome I shoot you don't even hit grain at 2040dpi. There's no point bogging down Photoshop if the driver is just going to throw away the excess resolution. Also, Epson drivers will croak with really oversized files.
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