Is your monitor calibrated and profiled? If you monitor is off, then it really becomes a guessing game of how to adjust the file. I use a Monaco Optix spider to do that job. Also in PS, use the "proof color" setting to get a better preview of what the image could look like, an check the "out of gamut" option as well (although desaturation should alleviate any out of gamut problems, but good to check anyway). Last but not least, the differences in color representation (additive vs. subtractive) will lead to some inconsistencies, however slight.
When I got into color printing also with an Epson R1800, I read Real World Colormanagement from Peach Pit Press, and also have the Focal Press Color Management for Photographers volume. It helped me a lot to get through all the new terminology.
I did notice when I printed some pure black & white images, that depending on ink-levels in the various colors, slight hues are introduced. Basically what you would see in warm-tone vs. cool-tone papers. Nothing I worry about, but when I compared some prints from different batches, it is quite noticeable.
Best wishes
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