If you stretch to the limit, and get a maximum legal carry on like the Think Tank Photo Backpack ($400!), you can get a compact 4x5 system and a small 35mm system onboard along legally, with reading material, a laptop, and toilitries - but it is very difficult. I did it with a Technika, 60 sheets of Readyloads, a second lens, Pentax meter, etc. a Nikon D70 and a couple small primes, all crammed into a Lowe Compu-Trekker (like the Mini Trekker but thinner to allow for a laptop compartment.
In the 80s I used a lightweight maxiumum legal carry on that was larger then. I really could pack a full 35-120-4x5 system. Gary Regester of Chimera and Plume fame used to give lectures and demos of how he did it. I used to haul a complete 3 body - 5 lens Nikon set, a Fuji GS690, and a Wista SP with three honker big lenses. But nowadays it is impossible to get all that onboard, unless you're talking about something radical like:
A Kerry Thalman style Toho 4x5 set up
A compact 120 rangfinder like a Mamiya 645i
and either Leica Ms or similar
None of these maximum carry-ons are any fun to carry or load onto a luggage bin.
For fun, I would simplify and take my FAVORITE camera and maybe a compact - and stop worrying and start shooting! The format is never as important as actually making the photo, and a good 35mm photo beats a mediocre 4x5 everytime.
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