One of my old jobs was taking photographs of Army and Air Force Battalions which they would get enlarged to 3 meters wide sometimes and stick at the end of the barracks. I did a bunch of tests on my 4x5 using a Super Symmar 150mm lens at f/11 f/16 f/22 and f/32. The results were scanned at 4000dpi. The f/16 were clearly sharper than the f/11 and f/22. The f/32 was significantly blurry in comparison. We're talking very large enlargements though
I also did a big camera comparison where I looked at the effective reduction in quality of image at various apertures.
at f/16 2/3 4x5 had an equivalent of of 205mp
f/16 2/3 = 205mp
f/22 2/3 = 157mp
f/32 2/3 = 115mp
So you've got a ball park for what stopping down can do to your results. Not many people scan 4x5 at 4000dpi though. I would guess you won't see much difference between f/22 and f/32 if you're scanning at 2000dpi but f/45 will degrade quite a bit. I have in my head that f/22 2/3 is the maximum I would prefer to go to.. f/16 2/3 is optimal. Obviously I'll shoot at whatever aperture gets the shot tough... 115mp is enough for me!!!!
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