For Epson 4990 + Epson Scan users...
As you may know, the 4990 features a single fixed lens, so choosing between "Film (with Film Holder)" and "Film (with Film Area Guide") doesn't change the performance of the lens. (It's a different story, of course, with Epson's later models such as the V700/750.)
However, the choice does make a difference on which part of the platen is covered by the 4990's lens. Naturally, the "Film Area Guide" provides a larger area, especially toward the bottom where I like to place my homemade film holder.
So I use the "Film Area Guide" choice -- even though I'm using my homemade holder.
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