"IMHO it's usually a no-brainer because insufficient depth of field (arising from using too wide an aperture because of worries about diffraction) in a photograph where everything is supposed to be sharp is usually far more noticeable and distressing than are the effects of diffraction with LF film and even a large (say 20x30) print. "
That assumes that the camera was properly focused so the near and far points will fall into the DOF at the largest useable aperture for those two points.
Too many people that we talk to over the years focus on the far point and then stop down until the near point appears sharp. And that ends up with apertures that are beyond the optimal ones for the lens design.
Also, the DOF attained is also effected by the magnification one wants for the print. Assuming you are using a 4x loupe and are checking the DOF at shooting aperture on 4x5 then you are seeing the DOF on a 16 x 20"print. If you then make a larger print you will no longer appear sharp at the same near and far points.
It is not just a matter of f64 and be dammed.
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