I suspect everyone will have a system and swear by it. For more than a decade I have used VueScan software exclusively. . .
https://www.hamrick.com
. . . to scan 35mm, medium format, and large format. I use an Epson 700 for large format, mostly 4x5 now, using the included Epson holders. I also have the Better Scanning setup, which I used for 5x7 on this scanner. And I will occasionally scan medium format and 35mm on the Epson, but only when I want a quick, smaller scan--see below.
I do most of my medium format scanning on an older Nikon 8000, which is much slower than the Epson but gives a much more detailed scan, IMO. Nikon made great scanners, but abandoned the product and software long ago, which is why I originally migrated to ViewScan. Hamrick keeps the software up to date for multiple scanners and operating systems, and it is just easier for me to use it for everything.
For 4x5, I scan Preview mode at 600 dpi, then scan to a TIFF at 3200 DPI. Yes, I have been advised that the scanner really can't go above 2000 dpi, but it works for me. I scan mostly black and white and use the deceptively named Color panel to get a rough approximation of the tones I want. (In my experience, getting well adjusted color scans is harder whatever software you use. But as I said, I shoot almost all black and white these days.)
I scan each medium format roll or large formate development session to a separate folder and then import the folder into Lightroom. Purists might be up and arms over this, but I love the Lightroom editing and exporting tools and being able to do my cataloging and keywording in the same program. I will only move a file into Photoshop if I need to do a lot of cleanup using Content Aware Fill or resizing for printing. Of course Photoshop then saves a new file back to the Lightroom catalog under a different name.
The TIFF files are very large, but periodically, I will save all but the very best as JPGS. And, of course, b/c I have the negatives I can always rescan if I want a more capable file for some reason.
Out of curiosity, I just checked my Lightroom catalog and see more than 10,000 TIFFs and JPGS from film exposed over 50 years--pretty much all of it scanned with VueScan. (This is in addition to the many digital images saved as dng.)
Hope this help.
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