Matthew,
I have the same Cambo that you have. Since I don't have a smaller, lighter camera, I take it with me where I want to take photos, and just deal with the weight. A good backback with a proper suspension system makes a lot of difference.
My backpack is a Kelty Redwing 2900. I purchased it on sale at REI, but I have seen it for a good price ($79) at Sierra Trading Post (www.sierraonline.com). This is an internal frame, front loading pack with a very good waist/hip and shoulder suspension system. I think that any pack with a good suspension system will do wonders for your shoulder! Most of the weight in my pack is carried on my hips. The shoulder straps are wide, and when everything is adjusted properly, it feels great. It is heavy, but once it is on, it does not feel as heavy as it does picking it up.
I purchased some heavy duty foam, and cut the pieces with an electric carving knife. There are cutouts for the camera, my lenses, and some of the accessories. Other accessories reside in the varous pouches on the exterior of the camera. One 1/2 inch piece of foam covers the whole bag. A thicker piece sits on top of it. That is the one with the cutouts. I put the camera in the bag, mounted on the short wide- angle rail. I keep a lens mounted on the camera. One thing I have found: Now that I have been using the camera this way for a while, I find that I want to get a new piece of foam to rearrange things.
Another alternative I am considering is to protect the camera somehow (perhaps just with the dark cloth, and protecting lenses and other valuable items in tupperware or similar containers. I have read that others use foam cutouts to hold and protect lenses inside the tupperware. It might be worth a try, because you will get more useable space in the bag. You do, however, lose some protection, and the organization that the foam liner provides.
One tripod leg fits through the cross country ski holder on the side of the bag. What a luxury! No need to carry the thing over my shoulder any more. The other ski holder holds my long monorail.
Another strategy that might make things more portable is to purchase an adapter board for the 45NX that allows it to accept Technika style lensboards. (Who knows, Calumet might even offer a Graphic to Cambo adapter. I never checked.) At least for lenses mounted on a flat board, this will save lots of room in your pack. My Technika to Cambo adapter was cheap (bought on E-Bay with 3 other boards for $99!) but the new ones cost almost $250! I have seen them go on E-Bay for $80- $100. You can get inexpensive, but nice, Technika style boards from Midwest Photo Exchange. They are made by Nikon.
I carry my film holders in an Eagle Creek day pack with the waist belt folded in. I just clip it to D-rings the outside of the pack. It holds 10 or so 2-sided holders.
This combination is less expensive than the photo backpacks. I think that the suspension system is better than that in most photo backpacks. The drawback is that you have to be creative in figuring out how to carry the camera and the other pieces, because it is not pre-divided.
I have used this system for day long hikes, and it works great.
Hope this helps.
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