It should be kept in mind that the resolution resulting from multiple steps in the process is LESS THAN that of each of the steps alone. That means that even the best possible scanner will reduce the resolution you end up with, but that may be only very slightly if the scanner is good enough.
There are two popular rules of thumb for calculating the combined resolution which are used in practice. If you start with the component resolutions about equal, then either rule tells you the resulting resolution will be significant reduced. When you scan a large format negative or transparency, there are at least three resolutions: that of the lens, that of the film, and that of the scanner. The first two will already reduce the resolution to something less than 50 lp/mm (perhaps much less). So you want the scanner to resolve significantly more than that if possible so that the scanning step makes only a small further reduction.
4800 ppi is the same as about 189 pixels per mm. But you have to divide that in half because you want LINE PAIRS, each of which requires two pixels. That gets you down to about 94 lp/mm. That would be large enough not to affect the final result enough to matter, if the scanner actually delivered that. Unfortunately, there is one more complication. The scanner rating tells you just how many pixels it collects without telling you the quality of those pixels in terms of resolving detail. Thus, a 4800 ppi scanner in reality might only deliver say 40 lp/mm. Scanners differ significantly in how close they come to providing the theoretical resolution the scanning rate would suggest. Typically, for example, a 4000 ppi scanner for 35 mm film will do better, for example, than a 4800 ppi scanner which can do large format. That is because it is easier to mainatin optical quality over the smaller format.
Unfortunately, if you scan at extremely high sampling rates, you get very large files, which require a lot of memory, a fast processor, and lots of storage space. So there are practical limits, as well as cost, in using a very high scanning rate. Also, you can improve the apparent sharpness of the image by various digital techniques. So unless you are making wall sized prints which you expect people to view from close up, you need not use such high resolution scanners. I am comfortable with what I've been able to get from my Epson 3200 scanner, at least for the present. I can produce a 16 x 20 print which will look sharp as long as the viewer stays at normal viewing distance. Some day I wlll get a 4800 ppi scanner, but I won't bother going beyond that.
But, if cost is no object, and you can manage the enormous files you would end up with, then get the highest scanning rate you can get, and make sure the optical quality of the scanner is high enough that you get something close to that scanning rate in practice. If you do that, the resolution you end up with will be determined primarily by the lenses and film you use, and you will have eliminated the scanner as a limiting factor in your work.
P.S. The high scanning rates provided by many consumer grade scanners are meant to be used with medium format or 35 mm. In practice you might not need to highest scanning rate for 4 x 5.
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