Make sure the scanner is on and warms up for at least 30 minutes to an hour and you shouldn't have problems with tonal shifts. I haven't seen any issues except when I didn't let the lamps warm up enough. I don't generally bother with strips though - there is plenty of resolution for almost any typical usage at the max it can scan in one pass. Medium format can be scanned at 5000 DPI, which is a lot. 4x5 can only get to 3000 DPI so I have sometimes scanned it in strips at a higher resolution when I've wanted to print really large. The file-size limit is 2GB (but in a newer OS you can get around that).
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