Kirk, here's a suggestion, which I do to all of my images to eliminate shadow noise. First, go into the shadows at 100%, and apply the dust & scratches filter. Use a radius of 1 and a threshold of about 25 or so. You might need another pass with radius of 2; that depends on the image. With a few tries, you should be able to completely eliminate the noise in the shadows, but the whole rest of the image will be messed up too.
Make a copy of the image, and paste it back as a layer on top of the old version. Now go into the advanced blending mode, and pull the sliders on the right (the highlights) down, so that the layer is only applied in the shadows. The sliders should be on something like 50 or 60. Using the option key you can split the sliders so that they fade in.
That way, the denoised layer only applies in the shadows. Now you can go back into the shadows and fade the layer's opacity to taste. I usually fade it partially back in, so there is a tiny amount of noise, so the shadows don't look too smooth.
Then, when you sharpen, you can do the same thing-- make a copy of the sharpened layer, put it on top of the non-sharpened layer, and use the advanced blending mode sliders to pull the sharpened layer out of the shadows. That way, the small amount of noise you leave in the shadows will not get sharpened.
Does that all make some sense?
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