Well, Angus mentioned "flatter film plane" of 4x5 versus 8x10. The bigger the film the more the sag if it's pointed somewhat downward, which is a common scenario in tabletop photography. But there are distinct ways to cure that, among the multitude of other relevant topics that can be researched on this forum. But in this case, the elephant in the room is the substantial cost of properly mounting and framing or otherwise displaying big prints at the end, which pretty much dwarfs film expense. Thumbtacks and push pins aren't exactly in style.