Actually, with the 4990, maybe not. The later V series scanners have a second lens focused a bit above the glass to accommodate film holders. So they can definitely benefit from a film holder. The 4990, however, does not. I sold off the film holder I had bought for this scanner because I found out I got much shaper scans by scanning directly on the glass. That discovery led me down the path of fighting Newton rings, which caused me to settle on wet scanning directly on the glass. That threatened to be very costly, but by using Dura-Lar instead of Mylar, and Ronsonol instead of Kami fluid, I saved a bunch of money. And in the end, it's probably less hassle than messing with a regular film holder, because there's less dust to deal with afterwards.
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