OK. I have been shooting color neg and making some pretty good display prints from 4x5 for 40 years +. IOW, I know how to make a very good C-print using the best pro equipment.

My question is, can someone tell me what difference(s) to expect when I switch to do-it-myself scanning (ie, 4990 or 750- not drum or Imacon) --still from color neg-- and Epson 7800 printing to 20x24. I know, most of you are way beyond this basic question and I'm late to the party, but really, when you literally put the prints side-by-side, what differences are there?