I think more than the brightness of the lens it depends on the contrast of your subject and how magnified your subject is.
I have an easier time focusing a portrait under contrasting modelling lights with my 480mm f/9 than a moody landscape with my 75mm f/4.5...
Of course all things being equal, a fast lens is much more comfortable to use. My 210mm f/4.5 is my most used lens because it’s just so nice to compose and focus with.
I have the 45N2 and with a 300mm at full extension I can do a head and shoulder portrait on 4x5, so on 6x9 you should be able to do headshots.
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