If I can remember it's history correctly, the profiles in Vuescan originated from the series of profiles Kodak produced for it's PhotoCD format (anyone remember that...?) - They are both of about the same vintage - and that is why it seems a rather odd selection of films, somewhat frozen in time.
As Vuescan evolved (and it does so every few days), I think most people tended to use it as the scanning end of a personalized workflow, rather than an end in itself.
Most of Ed's efforts have gone into making it compatible with almost every scanner under the sun.
It will still do a first rate job with colour transparency film. Also B&W using one of several approaches mentioned above (as well as NegPos - I've found picking one of the TMax CI profiles and tweaking it does work well)
For colour neg it was always a bit hit and miss - again, I've found a RAW colour scan + NegPos is excellent (I prefer it to silverfast - others don't - btw, with Silverfast, part of what you are paying for is the production of new/up-to-date profiles). Indeed, if you make the effort to profile your own choice of colour neg films with NegPos it is one of the best I've seen for converting colour neg scans
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