OP says negative printing and color separations, and the first thing may use diffusion.
Digital masking can be very useful for RA-4 optic printing. I allows "through the negative quality" while it adds some of the "hybrid flexibility". Imagine a wedding shot, a white dress would impose a color balance, but beyond that you may want (say) a cooler background and warmer skin tone, you may do that by editing a color correction mask in Ps that corrects color locally and dodges certain areas. You save time and materials. In that case you need some diffusion to hide the inkjet spots in the mask. Then you have solved most of the print, it may be left some manual burning.
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