Just as I expected -- if you ask 10 photographers for their opinion, you'll get 25 answers! In short, it all comes down to an opinion -- YOUR opinion. While I know that it is hard for you to have an opinion on formats that you haven't used, you can try it now with your current MF gear. If you can't get the results you want -- however you define that -- you can try a larger format.
I've done a lot of close-ups in B&W and Color from 8x11mm to 4x5" and made lots of LARGE prints -- up to eight FEET. I've got some GREAT (in my opinion) SIX foot prints taken with 35mm Kodak Plus-X. Sure, you can see the grain from a foot away, but due to the subject matter and normal viewing distance, it works great -- again, in my opinion. I've done the same with my Mamiya RB67 and TOKO NIKKI II 4x5. Yes, the 4x5" results have less grain -- depending on the film used. For example, my 35mm Ektar 25 shots hold up pretty well when compared to my 4x5" Agfacolor 125 shots. Another example? Back in the 80's, Peterson's Photography did a comparison of 35mm Agfapan 25 and 4x5" ISO 125 film and could not find any difference in the final prints.
What will you like? Only you will know. Push what you have to the limit. See if it works. You might just need a different film or technique -- instead of a different format.
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