One thing nice about placing the camera in a stuff sack (waterproof), is that if any knobs or screws actually worked themselves off, they'll be contained. I have memories of taking the camera out, and a knob would be loose in the bag.
The problem of vibration can be significantly reduced with padding, and until someone hooks up a vibration meter of some kind, I am going to assume that it is all about the same, on the bike or in a pack on my back. And if I crash, having equipment on the bike is safer than on my back -- for me and the equipment. Some of the toughest vibrations will come from the inside ones car. The last ten or so miles of wash-board road into Eureka Valley in my van probably caused as much vibration to me and equipment than the 2000 miles on a bicycle in New Zealand! LOL! I keep the camera gear on the foam mattress, which helps.
In NZ, there was fifteen km of the same kind of wash-board road down on the back side of Haast Pass...zooming down the pass on the loaded bicycle was intense. I had to keep a very loose grip on the handlebars or else my teeth would have shaken out. But the camera equipment was fine. As an after-thought that evening, perhaps letting a little air out of my tires for that downhill run might have helped.
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