Alan,
Don't let me scare you away from using a smaller aperture when necessary. However, be aware that an "optimum" aperture exists for just about every situation that balances depth-of-field and degradation due to diffraction. Many simply ignore diffraction, since its effects are small and really only become apparent at very small apertures together with a high degree of enlargement. I use f/45 occasionally when I need it; I just plan to keep the print size small enough that the diffraction doesn't bother me.
For more info see the article on the LF home page here: http://www.largeformatphotography.info/fstop.html . There are lots of other great articles there as well, which I highly recommend.
Best,
Doremus
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