If a sense of endless detail is central to the effect of the print, then there is a limit to how large an Epson scan can be enlarged. For me, that's about 4x or 5x, depending on subject material. But that is also for prints that can be inspected from the viewer's minimum distance, which is maybe 10 inches. If you can control how close the viewer can get, then you can print larger without losing that sense of endless detail.
Rick "noting that a sense of endless detail is only one of several attributes of large format" Denney