The thought of how much computing power would be needed to process image stacks from 4x5 (or even MF) digital back is mind-boggling. In short, you'd need nothing short of a $20,000 supercomputer!
Some of the medium-format backs are 50 megapixels. The Betterlight scanning have a 3x4in scanning area and range from 19 - 139 megapixels (for the 19MP one, those have to be the cleanest sharpest megapixels you'll ever see!). I don't know about your computer, but my computer is going to crash just thinking about doing an image stack of hundreds (or even thousands) of 19-139 megapixel images. Not to mention the size requirement: 50-400 MB per file times say 100 - 2000 stacks! That ranges from a DVD's worth of information (~5GB) to a hard-drive's worth of information (~271GB!).
I have a Q9550 Intel quad-core CPU, 8 GB RAM, and a 1TB 7,200rpm HD. Working with 4x5 files in GIMP alone sometimes can cause it to hit the virtual RAM (I forget what it is called...for he most part, with 8GB of RAM, you never hit the hard drive...except when doing significant transformations to 4x5 images).
I think that to work with many stacks of even higher end medium format digital images, you'd need a dual 12-core AMD operon machine with 256GB of RAM and a motherboard that could support that much. Price so far? ~$12,900.
These files are big, and normal hard drives are very slow (~133 MB/s)...so if you want to work with them in a reasonable manner, you'll need a very fast hard drive. The best consumer grade one at the moment is a ~$1700 400GB 270 MB/s hard drive. But that might not be fast enough! You might need something more like a 800 MB/s or even 1.5 GB/s read hard-drive: $7,500-$10,000.
Oh, and you can tack on an $200 SSD if you can't hook link your digital setup directly to your supercomputer.
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