I got rid of Time Machine and now use SuperDuper!.
I schedule a regular backup overnight, and it works flawlessly.
It will wake up the computer from deep sleep, do its thing, and put the computer back to sleep. Unlike TimeMachine, it will back up your email and other personal files - whatever you want, whenever you want. I can't recommend it more highly.
The feller who writes it, is a relative of our own John Nanian - another good reason to consider it.
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