If compartiments, padding, and quick access are a priority, i'd have to recommend the lowepro trekker bags (several sizes to choose from) which have a better suspension system and construction than other photo backpacks I have seen. If comfort is a priority, try a regular front-loading backpack. I like the Dana Designs. When going on a long hike when most of the time is spent hiking, I am use the Dana Swiftcurrent, otherwise the Lowepro Super Trekker.
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