I have Vuescan and FotoLook v. 3, and I prefer FotoLook with my Agfa scanner. I usually can save some PhotoShop work by adjusting curves and levels in FotoLook. I've posted a bunch of my FotoLook curves for different films and film/developer combination as a ZIP file around here somewhere, which you should be able to turn up with a search.
I have an original Duoscan and have had a Duoscan T1200, but the Duoscan has gotten streaky.
I find I get much sharper results by using the glass tray with a sheet of glass on top of the neg or transparency than I do with the open film carriers.
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