I would love to be standing for a portrait while the photographer consults a depth of field table Unless you are using additional lighting, such as strobe, start with the shutter speed you can get away with and then accept the f-stop you have to live with. You may not be able to get 1/125 and f/45. In which case you have to compromise on either risking blur from motion or blur from not holding enough depth of field in a group photo. Sometimes it is impossible.
You quickly run out of light, which is why you just can't do some things with only natural light. So you give a "what the hell" lucky try or go learn about lighting.
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