There have been major improvements in Vuescan over the past 6 months. I moved back to it from Silverfast because of the greater control I get. Bicubic sharpening while downsampling is not really sharpening in the sense that I think you are thinking about. It is just a modification in how the downsampling algorithm handles the averaging of the data points. (This is in CS2 or Picture Window Pro.)
My best workflow is to scan at 4800 DPI, output the raw scan from Vuescan, downsample it in CS2 to 2400 DPI with bicubic sharpening at the default value, invert, then use LEVELS (not curves) to scale the data. I also use 4x multi-sampling, which is supported on the Canon 9950, so it takes 4 data points before incrementing to the next scan point. This gives the effect of 16 data points being averaged for each data point in the final file, which helps noise a lot. Since it is easy to upgrade Vuescan, invest an hour and give it a try. It is not going to turn your scanner into an Imacon, but if it improves your scan even a little it could make a difference in a 16 x 20. Paul and I have kicked around the 1800 compared to the 9950 - it is hard to resolve, but I think you can do as well or better with the 4990 and optimizing the workflow. The Microtech 2500 would be a much more logical step up, but they seem to be discontinued.
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