You know, I can't think of a 120 back on a medium format or large format that I can load one-handed. While I am sure you have adapted with a much higher degree of creative dexterity than I have, it probably makes sense to determine what kind of back is the best for you to load, and base the rest of your system on using that back - whether it is a Hasselblad A-12, a Rollei SL66, a Fuji or one of the large format roll backs from Horseman, Linhof, Graflex, etc.
I'd imagine any spring-loaded locking knobs could be defeated with lock washers and a little destructive machining.
I'd also venture that a sturdy tripod and mounting system would be a large benefit, as it would provide the required stability for attaching backs and making movements. So maybe it means a heavier, more expensive tripod and a lighter, cheaper camera....
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