I've noticed that when I choose anything over 2400dpi 48bit for my 4x5 negatives I receive a message stating something to the effect of size is too large for the area selected. Obviously it won't scan. I own a v850. I would like to be able to push it to 3200 in 16bit ( 48bit ) for my color negatives.

I dont have this issue with Silverfast but have noticed some color scans look much better via Epson scan, specifically Portra 400. I am using a MacBook with 16gb ram 2015 and the OS version prior to the latest version.