As I recall, Karsh shot a number of his head-and-shoulders portraits (like the Humphrey Bogart one) with a 14" Commercial Ektar at f/22. I saw a print of that in person, probably no bigger than 11x14, and he'd very skillfully manipulated Bogart's position to draw attention away from the out of focus parts. In that case, the more distant shoulder is obstructed by Bogart's face, and his hands are not only in the same plane as his face, but the palms appear to be touching near the wrist, even though the fingers are fanned apart from each other. The near shoulder is printed way down near zone II, and a raking light, a hard light, is picking up the texture of his tweed jacket, though in some prints, most of the shoulder is cropped out!
For example:
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