Dennis,
I have the 150S and it is incredibly sharp. It is a lens that Kerry Thalmann has on his "future classic" list. I have used it at all distances, and have never noticed any problems. Of course, this is just my opinion without doing any so called testing. But my images from the 150 Sironar S are tack sharp at all distances, including infinity. I sold my 150N to get the S and never regretted the move. For 4x5 it is a tremendous lens.
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