Keep output size the same as the film size. That's how most people refer to scanner resolution. "Output size" is a remnant from 1990s pre-press work. Today, most scans are done at the best resolution for the film, which includes film size, type ...., and then resized as needed in Photoshop to make prints. Scanning takes time, and so it's usually most efficient to scan once instead of making many scans for different sizes. Always archive the original scan. In other words, treat it like a negative. If you overwrite it at a lower res, you'd have to re-scan.
Consumer flatbeds, such as yours, do best with bigger film. As long as you keep the enlargement size down to about 4x, and your workflow, especially how you sharpen the file, is up to snuff, you can get good results, especially if your film doesn't get too dense. The specs put out by consumer scanner companies are bogus, especially the dmax and max resolution numbers.
With a flatbed, I've found that finding the proper height for the negative is very important. I'm not sure if your scanner is auto or set focus, but with Epsons the best result is often with the film raised a bit. It also needs to be kept flat.
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